All other parameters did not change significantly. All structured data from the file namespace is available under the. Before Unauthorized use of these marks is strictly prohibited. [20–22]. Zum Charité-Portal. Eur Rev Med Pharmacol Sci. [12] It was also considered the best medical school in Germany by Times Higher Education 2021, being the eighth in Europe. VC is named together with Euroimmun GmbH on a patent application filed recently regarding the diagnostic of SARS-CoV-2 by antibody testing. The latter group is often called middle molecules, consisting of compounds between 15 and 45 kDa such as β-2-microglobulin, tumor-necrosis factor alpha (TNF-α), interleukins, complement factor D and others, many of which are pro-inflammatory [1]. Zitt E, Davidovic T, Schimpf J, Abbassi-Nik A, Mutschlechner B, Ulmer H, Benda MA, Sprenger-Mähr H, Winder T, Lhotta K. Front Immunol. Berlin and O. Dorligjav at the KfH Nierenzentrum Halle (Saale). An der Charité führen wir deswegen das sog. There were no significant differences between the patients randomized to MCO first or to High-flux first. Cellular and Humoral Responses in Dialysis Patients after Vaccination with the BNT162b2 or mRNA-1273 Vaccines. Although adverse effects or even toxicity has not been proven for all of these substances, many of them are factors or at least indicators of unfavorable outcome. Gerade weil es sich bei Nierenkrebs um eine seltene Tumorerkrankung handelt ist die Expertise und Erfahrung des Operateurs von großer Bedeutung. In general, the log transformation provided acceptable fit to normal distribution for the lab values and vital signs under investigation. PLOS is a nonprofit 501(c)(3) corporation, #C2354500, based in San Francisco, California, US. doi: 10.1371/journal.pone.0281160. The present study has a number of advantages over previous trials on this matter. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. Translation of "Nierenzentrum" in English. The study was registered at ClinicalTrials.gov (NCT02084381). Manchmal ist die lokale Entfernung des Tumors in der Niere alleine nicht ausreichend zur Krebsbehandlung und man muss auch einen Weg finden, weiter entfernt liegende Tumorzellen anzugreifen. With numerous Collaborative Research Centres of the German Research Foundation it is one of Germany's most research-intensive medical institutions. Michael Hulko, See below. This trial was conducted with the aim to examine the effects of MCO dialysis on markers of inflammation and uremic toxins. It therefore, remains somewhat unclear whether the effects on serum concentrations of the investigated parameters are due to reduced production or enhanced elimination. 10.1056/NEJMc2102051 The use of MCO-Ci reduced the primary endpoint TNF-α and IL-6 mRNA expression in peripheral blood to a significantly greater extent compared to High-flux dialyzers. Though the majority of its original and pre-War structure was damaged or destroyed during the War, it nevertheless was used as a Red Army hospital. The patient is receiving treatment from Dr. Stephan Walter at MVZ Nierenzentrum Limburg, a specialist kidney center. 2023 Feb 8;13(2):474. doi: 10.3390/life13020474. Number of patients with serious adverse events while being treated in the study (+ 15 days after end of study). Copyright © 2023 British Society for Rheumatology. 2020 – 2026, Executive Committee of the KDIGO Guideline Initiative 2020 - 2022, Nephrology, Dialysis & Transplantation (Theme Editor). The trial was not blinded neither to patients nor to physicians, while laboratory staff remained blinded until data was cleared and the database closed.[11]. Fig 1 denotes the patients’ flow chart during the trial periods. The tailored pore sizes of these MCO-Ci membranes promote removal of large toxins while ensuring the retention of albumin. (KfH dialysis centers at University of Halle/Saale and Charité Campus Virchow University Hospital Berlin, Germany) The first patient was included February 10th 2014, the study was finished July 29th 2014. . Nierenzentrum Charlottenburg Wilmersdorfer Straße 57 10627 Berlin-Charlottenburg Fax. [31] Research fellows include: 52°31′36″N 13°22′47″E / 52.52667°N 13.37972°E / 52.52667; 13.37972. This effect is presumably related to direct receptor stimulation and additional allosteric effects, at least in heterodimeric receptor constellations. BNT162b2 COVID-19 vaccine and correlates of humoral immune responses and dynamics: a prospective, single-centre, longitudinal cohort study in health-care workers. Am häufigsten findet sich mit ca. A time effect (crossover period 2 > crossover period 1) was significant only in Berlin (p < 0.001), but not in Halle (p = 0.168). Gambro AB (including all direct and indirect subsidiaries) is part of Baxter International Inc. Markus Pawlak and Michael Templin are employees of the NMI Technology Transfer GmbH. Hemodiafiltration (HDF) in post-dilution mode provides even more efficient removal of uremic retention solutes compared to High-flux [6]; however, the debate on improvements of clinical endpoints by HDF is still ongoing: three recent prospective randomized studies gave conflicting results regarding the benefit of HDF on mortality [7],[8, 9]. In 2003 the Berlin city and state House of Representatives passed an interim law unifying the medical faculties of both Humboldt University and Freie Universität Berlin under the roof of the Charité. In 11 of the 16 SAEs, patients fully recovered, one death occurred during the High-flux period (Table 5). Disclaimer. Je weniger die Tumorzellen noch wie normale Nierenzellen aussehen, umso aggressiver der Tumor. Epub 2021 Jul 2. From Wikimedia Commons, the free media repository. Thermal cycling conditions were performed according to manufacturer’s instructions. Cozzolino Mario, Ketteler Markus, Wagner Carsten Alexander. The plasma levels before and after the 4 weeks cross-over phases are listed in Table 3. sharing sensitive information, make sure you’re on a federal 2021 Aug;70:103524. doi: 10.1016/j.ebiom.2021.103524. Your comment will be reviewed and published at the journal's discretion. Here, we report the results of a clinical trial using the MCO-Ci dialyzer for up to 12 weeks in a randomized, prospective, cross-over design in 50 chronic dialysis patients. Bei uns werden Kinder und Jugendliche mit Nierenkrankheiten in enger Zusammenarbeit mit der Charité Universitätsmedizin, Klinik für Pädiatrie mit Schwerpunkt Gastroenterologie, Nephrologie und Stoffwechselmedizin behandelt. Serum samples were analyzed by SARS-CoV-2 specific IgG and IgA antibodies ~1, ~3-4 and ~10 weeks after the second vaccination. Many of these uremic toxins are not cleared by standard extracorporeal treatments, either because they are protein-bound or because their molecular weight exceeds the pore size of the membrane used. ein Kontrastmittel-CT oder Kontrastmittel-MRT, handeln. The company is headquartered in Weinheim, Baden-Wuerttemberg, Germany. Even though no significant carryover effect was noted in the statistical analysis, it can be suspected that the MCO treatment caused longer lasting effects than expected. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong. Sprechstunden der Klinik für Nephrologie und Intensivmedizin. Christian Henning, [7] Several politicians and diplomats have been treated at the Charité, including German Chancellor Angela Merkel, who underwent meniscus treatment at the Orthopaedic Department, Yulia Tymoshenko from Ukraine, and more recently Russian opposition leader Alexei Navalny, who received treatment at the hospital due to his poisoning in August 2020. Die Medizinische Klinik mit Schwerpunkt Nephrologie und Internistische Intensivmedizin (CVK/CCM/CBF) betreut Patientinnen und Patienten mit allen Formen und Stadien von Nierenerkrankungen sowie Patienten und Patientinnen aus allen Bereichen der Inneren Medizin, die einer intensivmedizinischen Betreuung bedürfen.Nierenerkrankungen und Bluthochdruck sind in der Bevölkerung weit verbreitet. Anhand dieser Informationen zusammen mit den Ergebnissen der präoperativ durchgeführten Bildgebung teilt man das Krankheitsstadium dann nach der TNM-Klassifikation ein (siehe Abbildung). This article is about the hospital. By design, our trial focuses on surrogate parameters. Citation: Zickler D, Schindler R, Willy K, Martus P, Pawlak M, Storr M, et al. Imputation of missing values was not performed. PMC The admission rate of the reorganized medical school was 3.9% for the 2019–2020 academic year. Recently, a new membrane type with a steeper and lower cut-off, called medium cut-off membrane (MCO-Ci) has been developed [14]. Je früher wir die Erkrankung erkennen, umso besser. Während bis vor ca. <25 Employees . Bookshelf [30] In addition, it is part of the Berlin University Alliance, receiving funding from the German Universities Excellence Initiative in 2019. In accordance with the results of the PERCI-I-trial, levels of sTNFR1 were lowered significantly better with MCO-Ci dialysis compared to High-Flux. -, Bradley T, Grundberg E, Selvarangan R, LeMaster C, Fraley E, Banerjee D, et al. The Charité has four different campuses across the city of Berlin with a total of 3,001 beds:[20][1]. Das Nierenzentrum Reutlingen - Bad Urach ist eine internistische Gemeinschaftspraxis mit drei Praxisstandorten in Baden-Württemberg und widmet sich der Vorbeugung, Diagnostik und Behandlung von Nieren- und Hochdruckerkrankungen. Proving a clinical advantage of more efficient dialysis techniques has been difficult. Do not use an Oxford Academic personal account. Das Nierenzentrum verfügt immer über qualifiziertes Pflegepersonal und medizinisches Personal, mit denen Sie Ihre Probleme besprechen können. Patients had to have a permanent vascular access (fistula, graft or a tunneled central venous catheter). Throughout the whole trial all patients were treated with hemodialysis, hemodiafiltration was not conducted. COVID-19 vaccines: comparison of biological, pharmacological characteristics and adverse effects of Pfizer/BioNTech and Moderna Vaccines. Wie bei vielen anderen Krebsarten gibt es einige Risikofaktoren, die die Entstehung einer Nierenkrebs-Erkrankung begünstigen können. weitere Untersuchungen notwendig sein. Quantitative variables were assessed for normal distribution. In a preceding clinical trial, the characteristics of MCO membranes were examined in single-session and it has been shown that these dialyzers provide improved clearance for middle molecules compared to High-Flux dialysis and High-Flux-Hemodiafiltration. Register, Oxford University Press is a department of the University of Oxford. ; 2 MVZ Nierenzentrum Limburg, Im Großen Rohr 14, 65549 Limburg, Germany. Die nephrologische Ambulanz am Campus Virchow-Klinikum ist spezialisiert auf die Behandlung von Patienten und Patientinnen mit Nieren- und Hochdruckkrankheiten. The institutional subscription may not cover the content that you are trying to access. . Marcus A. Glomb, Blinding for periods (time sequence) was not possible, as study deviations only appeared in crossover period 2 or during the extension part of the study. The present clinical trial examined the middle-term effects of the newly developed MCO-Ci membranes. Primary endpoint was the gene expression of TNF-α and IL-6 in peripheral blood mononuclear cells (PBMCs), secondary endpoints were plasma levels of specified inflammatory mediators and cytokines. Campus Benjamin FranklinHindenburgdamm 30 12203 Berlin. Charité extends over four campuses, and has over 100 different Departments and Institutes, which make up a total of 17 different CharitéCenters. Affiliations 1 Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin Germany. [ view less ], Affiliation: Serum albumin, CRP, urea, creatinine, electrolytes, hemoglobin and platelets were measured at the central laboratories of the local university clinics. Based on results from earlier clinical trials conducted with HCO dialyzers [11] we chose to examine the pre-dialysis TNF-α and IL-6 mRNA expression level in peripheral blood mononuclear cells (PBMC) before and after each 4-week cross-over period as the primary endpoint. sTNFR1 is known as a predictor of cardiovascular mortality in chronic dialysis patients [23]. Our results show that both TNF-α and IL-6 mRNA are lowered to a greater extent with MCO-Ci compared to High-flux. FOIA Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. Weiter unten finden Sie eine Hinführung zu weiteren Informationen der einzelnen Sprechstunden. Inclusion criteria included age between 18 and < 99 years and CKD G5 (GFR <15ml/min/1.73m2) requiring hemodialysis treatment thrice weekly since at least three months. Wir empfehlen daher immer, sich nur an Zentren zur Behandlung zu wenden, die diesen Eingriff häufig durchführen. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. National Library of Medicine Fragen Sie Ihren Operateur ruhig, wie viele dieser Operationen er im Jahr durchführt. Thank you for submitting a comment on this article. Some societies use Oxford Academic personal accounts to provide access to their members. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more. Thus, trials with longer lasting treatment periods and clinical endpoints are desirable to analyze this matter further. For librarians and administrators, your personal account also provides access to institutional account management. Clipboard, Search History, and several other advanced features are temporarily unavailable. Bethesda, MD 20894, Web Policies Intracellular inflammatory parameters are hence better suited than plasma levels as markers of microinflammation. HHS Vulnerability Disclosure, Help To increase the removal of middle-sized uremic toxins a new membrane with enhanced permeability and selectivity, called Medium Cut-Off membrane (MCO-Ci) has been developed that at the same time ensures the retention of albumin. Twelve weeks treatment with MCO-Ci was well tolerated regarding the number of (S)AEs. [8][9][10], In 2010–11 the medical schools of Humboldt University and Freie Universität Berlin were united under the roof of the Charité. Read More. Nierenzentrum Zehlendorf, Berlin, Germany. In 2001, the Helios Clinics Group acquired the hospitals in Buch with their 1,200 beds. -, Crespo M, Collado S, Mir M, Cao H, Barbosa F, Serra C, et al. EBioMedicine. Roman Fiedler, and transmitted securely. Unauthorized use of these marks is strictly prohibited. Moreover, therapy with immunosuppressive drugs and concurrent participation in another interventional study were exclusion criteria. durch die (nicht-)Weitergabe von bestimmten Signalen direkt auf das Krebswachstum Einfluss nehmen können. 16 serious adverse events (SAE) occurred throughout the trial (Table 5). Sollte ein Verdacht auf Metastasen bestehen, können evtl. There was a significant decrease in serum albumin in the MCO-Ci phase (from 37.0±3.6 to 35.3±3.7 g/L, p<0.01) while albumin remained stable in the High-flux phase (baseline: 36.6±3.2, 4 weeks: 37.5±2.7 g/L). Oberacker T, Fritz P, Schanz M, Alscher MD, Ketteler M, Schricker S. Enhanced Oxidative DNA-Damage in Peritoneal Dialysis Patients via the TXNIP/TRX Axis. Clipboard, Search History, and several other advanced features are temporarily unavailable. Diese Behandlung ermöglicht ein Leben ohne Funktion der eigenen Niere, zugleich eine weitgehende Rehabilitation bis zur Arbeitsfähigkeit. 10 more...], Search for other works by this author on: Oxford Academic . Listed are only those parameters that changed significantly during the MCO-Ci phase. Kappa and lambda free light chains (FLC), β-2-microglobulin and myoglobin were quantified by nephelometry on a Siemens BN Prospec Analyzer (Siemens, Marburg, Germany) with Freelite FLC detection kits (The Binding Site, Birmingham, UK) or BN Prospec System reagent kits for β-2-microglobulin or myoglobin (Siemens, Marburg, Germany) as previously described [17–19]. The Safety and Immunogenicity of the mRNA-BNT162b2 SARS-CoV-2 Vaccine in Hemodialysis Patients. Having marked its 300-year anniversary in 2010, Charité is now one of the largest employers in Berlin, employing 18,200 staff (or 21,600 if including its subsidiaries). 910 were here. As shown in Table 4, serum albumin was stable after 8 weeks with High-flux (37.6 to 37.9 g/l), and increased non-significantly after 8 weeks with MCO-Ci (35.7 to 36.4 g/l). Competing interests: We have the following interests: Markus Storr, Torsten Boehler, Michael Hulko, and Kristin Werner are employees of Gambro Dialysatoren GmbH, Research & Development, Hechingen, Germany. Anschließend werden die Informationen der TNM-Klassifikation zur Stadieneinteilung nach UICC zusammengefasst, welche die Grundlage für weitere Behandlungsschritte bildet. Fernandes MDCR, Vasconcelos GS, de Melo ACL, Matsui TC, Caetano LF, de Carvalho Araújo FM, Fonseca MHG. The randomized crossover trial in 48 patients compared MCO-Ci dialysis to High-flux dialysis of 4 weeks duration each plus 8 weeks extension phase. [6] More than half of all German Nobel Prize winners in Physiology or Medicine, including Emil von Behring, Robert Koch and Paul Ehrlich, have worked at the Charité. . From 2012 to 2022, it was ranked by Focus as . Björn Hegner and others, Autoimmune activation and hypersensitization of the AT1 and ETA receptors contributes to vascular injury in scleroderma renal crisis, Rheumatology, Volume 62, Issue 6, June 2023, Pages 2284–2293, https://doi.org/10.1093/rheumatology/keac594. 10.2215/CJN.02160311 The proportion of males was higher (69.4%) than females. You are welcome at Herz- und Nierenzentrum Aare, group practice for a medical appointment in Solothurn. [11] We did not conduct systematic measurements of albumin concentrations in the dialysate. IL-6 and TNF-α are important inflammatory proteins in the process of inflammation and correlate with cardiovascular events in the dialysis population. Antibody and T cell outcomes at this timepoint were compared to a group of 44 elderly patients not on dialysis, after immunization with Tozinameran. The intention to treat population consisted of 48 patients while 47 completed the cross-over phase and 44 patients the extension phase per protocol (Fig 1). MeSH This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. SARS-CoV-2 specific humoral responses in…, SARS-CoV-2 specific humoral responses in vaccinated and unvaccinated dialysis patients and vaccinated non-dialysis…, MeSH The total duration of the study including the initial run-in phase was therefore 24 weeks. Bitte beachten Sie dazu auch unsere Fotos Nr. Antibody Responses After a Single Dose of SARS-CoV-2 mRNA Vaccine. In addition, thirteen research groups cover the entire field of neuroscience: from . The Charité is one of the main partners of the Einstein Foundation, which was established by the city and state of Berlin in 2009. Please enable it to take advantage of the complete set of features! Microbiol Spectr. 8600 Rockville Pike Daniel Zickler, 10.1056/NEJMoa2027906 In addition, SARS-CoV-2-specific T-cell responses were assessed at ~3-4 weeks by an interferon-gamma release assay (IGRA). The Charité encompasses more than 100 clinics and scientific institutes, organized in 17 different departments, referred to as Charité Centers (CC): Overall, 13 of those centers focus on patient care, while the rest focuses on research and teaching. AREG; EGFR; cAMP; phosphodiesterase 3A; renoprotection. Bogusz Trojanowicz, The company is headquartered in Reinbek, Schleswig-Holstein, Germany. Moreover, the number of clinically overt side effects was similar in both treatment arms and no AE related to hypalbuminemia was reported. Gambro Dialysatoren GmbH provided support in the form of salaries for authors Markus Storr, Michael Hulko, Torsten Boehler and Kristin Werner, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. 15.000 Menschen, davon sind zwei Drittel der Betroffenen Männer, ein Drittel Frauen. Co-immunoprecipitation experiments indicated heterodimerization between both receptor types which may enable the observed functional interrelation by direct structural interactions. The .gov means it’s official. 2020;24 (5):477-488. doi: 10.1080/14728222.2020.1743680. Note that the regression line of the MCO phase is lower and does not cross the line of the High-flux period; the difference between High-flux and MCO is significant, p<0.01. View the institutional accounts that are providing access. The rat models have the same PDE3A mutation as human patients (PDE3A stands. Identification of deliverable drugs for treatment of PD patients in clinical practice, Establishment of a directional peritoneal model, International Society of Nephrology (ISN), Council Member of the ERA 2009 – 2018, Congress President of the Annual ERA Congress 2021 in Berlin, Co-Chair of the KDIGO CKD-MBD Guideline Update 2015 – 2017, Board member of the Kidney Health Initiative (KHI) of the American Society of Nephrology (ASN) from 2017 – 2019, Board of Directors of the „Kuratorium für Dialyse und Nierentransplantation“ (KfH e.V.) Nierenzentrum is a company that operates in the Hospital & Health Care industry. For data evaluation, DataAssist Software (Life Technologies) was employed. Asbest, Arsen, Blei) sowie einen übermäßigen Gebrauch von Schmerzmitteln in der Vorgeschichte. Furthermore, we only used both dialyzers in a diffusive mode and cannot state whether MCO-Ci dialysis is superior to HDF regarding the elimination of middle-sized molecules. Patienten mit chronischen Nierenleiden, d.h. mit sehr geringer oder keiner Funktionstüchtigkeit der Niere, werden zweimal in der Woche 10 bis 12 Stunden an die Künstliche Niere angeschlossen. It investigated the middle-term effects of dialyzers on cytokine levels and inflammatory parameters. Participation in the trial was impossible, if patients were unable or unwilling to give informed written consent, or were pregnant or breast feeding, had a clinically manifest infection or a CRP value of over 50 mg/l in the last two weeks. Moreover, we saw a difference regarding the results during both treatment periods and in the extension period. Dazu zählen zum Beispiel Rauchen, Übergewicht und Alkohol, aber auch ein Umgang mit Lösungsmitteln, Schadstoffen (z.B. Die Diagnose „Nierenkrebs“ trifft laut Robert Koch-Institut in Deutschland jährlich ca. Department of Research and Development, Gambro Dialysatoren GmbH, Hechingen, Germany, Affiliation: eCollection 2023. This site needs JavaScript to work properly. : +49 30 310 078 689 E-Mail: mail@nzcb.de 3. . (http://www.gambro.de/). government site. Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates. Campus Charité MitteChariteplatz 1 (Geländeadresse: Luisenstraße 13) 10117 Berlin. We appreciate the help of the nurses and doctors of the dialysis centers where the study took place, especially Dr. Hörstrup and Dr. C. Pohle at the KfH Nierenzentrum Bismarckstr., Berlin and O. Dorligjav at the KfH Nierenzentrum Halle (Saale). official website and that any information you provide is encrypted Dr. Grêt, Dr. Novak specialize in cardiology; Dr. Farese specializes in nephrology; For further information or to book an appointment, call at 032 488 10 10. The dialysis regimen of each patient including blood flow, dialysate flow and treatment time duration per session was not altered. The level of significance was 0.05 (two-sided) but only the primary endpoint was tested confirmatory. Im Ergebnis der Forschungsarbeit der letzten Jahre entstand ein komplexer Maßplatz, der es gestattet, die Patienten mit einer in der DDR hergestellten Geräte-Kombination zu untersuchen. In future trials a mere parallel group design thus appears preferable. PLoS ONE 12(1): There were no changes to the protocol during the conduct of the study. doi: 10.1128/spectrum.03445-22. Symptome wie ein tastbarer Tumor, Flankenschmerz oder Blut im Urin müssen nicht unbedingt auftreten und können eher auf eine fortgeschrittene Erkrankung hindeuten. This analysis of more than 3100 Saxonian study participants directly compares for the first time SARS-CoV-2 vaccination induced humoral and cellular immune response rates and qualities in immunocompetent medical personal, immunocompromised dialysis patients, and immunosuppressed kidney transplant recipients at four to five weeks after the second vaccine dose. No interaction terms with treatment were significant. Corrections, Expressions of Concern, and Retractions. This is an important aspect that has to be evaluated in future trials. [11] QS World University Rankings 2019 ranked the Charité Medical School as number one for medicine in Germany and ninth best in Europe. For quantification of interleukin-6 (IL-6) the Quantikine HS human IL-6 ELISA kit, for complement factor D (CFD) the human CFD ELISA kit, for uPAR the human uPAR ELISA kit (R&D Systems, Minneapolis, USA); for α1-microglobulin (α1M) the 1M ELISA kit (Abcam, Cambridge, UK); for YKL-40 the MicroVue YKL-40 ELISA kit (Quidel, San Diego, USA) were used according to manufacturers’ instructions. Ralf Schindler, The uremic syndrome is characterized by retention of a large number of solutes that are normally eliminated by the kidney [1, 2]. Mo, Di, Do, Fr 8 - 12 Uhr Mo 16-18 Uhr nach Vereinbarung Telefon Praxis Mit diesem Link können Sie die aktuell aufgerufene Seite weiterempfehlen: © 2023 Charité – Universitätsmedizin Berlin. Overall, 36 patients completed the observation period until three weeks after the second dose and 32 patients were further analyzed at week 10. This page was last edited on 10 September 2020, at 10:48. Sie können die Seite mithilfe Ihres Browsers größer oder kleiner anzeigen lassen. Correspondence to: Rusan Catar, Department of Nephrology and Critical Care Medicine Campus Virchow Klinikum, Charité – Universitätsmedizin Berlin Augustenburger Platz 1 13353 Berlin, Germany.