1998;9:629-635. It is also a key player in the function and development of brain and nerve cells. Dementia and cognitive function Albert, C. M., Cook, N. R., Gaziano, J. M., Zaharris, E., MacFadyen, J., Danielson, E., Buring, J. E., and Manson, J. E. Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. Am J Cardiol. Heart disease and stroke Acta Med Scand 1974;196:525-6. Treatment of mild hyperhomocysteinemia in renal transplant recipients versus hemodialysis patients. Carmel R. How I treat cobalamin (vitamin B12) deficiency. Certain groups of people may not get enough vitamin B12 or have trouble absorbing it: Your body stores 1,000 to 2,000 times as much vitamin B12 as you’d typically eat in a day, so the symptoms of vitamin B12 deficiency can take several years to appear. 1995;32(8):876-880. Taking vitamin B12 by mouth, alone or with folic acid and vitamin B6, doesn't seem to improve memory and thinking skills in elderly people who have a decline in these skills. Accessed Aug. 18, 2021. 1968;21(1):57-67. The role of vitamins in the prevention and control of anaemia. View abstract. A vitamin B12 deficiency can deplete your energy, cause heart palpitations, numbness, or tingling in hands and feet. View abstract. Haker, E. and Lundeberg, T. Acupuncture treatment in epicondylalgia: a comparative study of two acupuncture techniques. View abstract. View abstract. Have a question? To provide you with the most relevant and helpful information, and understand which A randomized control trial of vitamin E therapy in the prevention of anemia in low birth weight (LBW) infants. Arterioscler.Thromb. Inhalt der Packung und weitere Informationen View abstract. New York: Academic Press;1975. View abstract. B., Vermaak, W. J., van der Merwe, A., Becker, P. J., Delport, R., and Potgieter, H. C. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. 2009;54(3):478-489. Vitamin B12 is an essential nutrient that your body can't make on its own, so you need to get it from your diet or from supplements. Jansen RJ, Robinson DP, Frank RD, et al. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. Res Nurs Health. Volkov I, Rudoy I, Freud T, et al. J Natl Cancer Inst 2012;104(20):1562-75. View abstract. privacy practices. Br Med J 1980;280:1214-5. Curr Opin.Clin Nutr Metab Care 2007;10(1):32-39. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. JAMA 2013;310:2435-42. Am.J Clin.Nutr 2006;84(2):361-370. View abstract. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. Am J Clin Nutr 2000;72:324-32. Nutrients. View abstract. Weiss, N., Pietrzik, K., and Keller, C. [Hyperhomocysteinemia, a risk factor for atherosclerosis: causes and effects]. View abstract. Accessed Aug. 18, 2021. Eine Überdosierung an Vitamin B12 ist aber möglich bei: Lebermetastasen. Tyrer LB. Liu, T., Soong, S. J., Alvarez, R. D., and Butterworth, C. E., Jr. A longitudinal analysis of human papillomavirus 16 infection, nutritional status, and cervical dysplasia progression. Exp Clin Endocrinol.Diabetes 1996;104(4):311-316. We currently have no information for VITAMIN B12 overview. J Renal Nutr 2001;11:67-72. You should not use Vitamin B12 injection if you are allergic to cobalt, or . Arzneimittelforschung 1979;29:97-81. New York, NY: McGraw-Hill, 1998. Etgen, T., Sander, D., Bickel, H., and Forstl, H. Mild cognitive impairment and dementia: the importance of modifiable risk factors. View abstract. Proc.Nutr Soc. Plasma homocysteine as a cardiovascular risk factor: causal, consequential, or of no consequence? View abstract. JAMA 10-15-2008;300(15):1774-1783. Megaloblastic macrocytic anemias. Indian J Pediatr 2002;69(10):903-904. The RDA is 2.4 mcg daily for people 18 years and older. Arch.Gerontol.Geriatr. View abstract. View abstract. View abstract. 1998 ed. B., van der Beek, E. J., Orlebeke, J. F., and van den Berg, H. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Obes Res Clin Pract 2021;15(2):177-179. Stevens, D., Burman, D., Strelling, M. K., and Morris, A. Folic acid supplementation in low birth weight infants. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. View abstract. Peppard L, Oh KM, Gallo S, Milligan R. Risk of depression in pregnant women with low-normal serum Vitamin B12. View abstract. 2020;30(3):304-305. BMC.Geriatr. Expert Opin Investig Drugs 2000;9:2637-51. Marcucci, R., Zanazzi, M., Bertoni, E., Rosati, A., Fedi, S., Lenti, M., Prisco, D., Castellani, S., Abbate, R., and Salvadori, M. Vitamin supplementation reduces the progression of atherosclerosis in hyperhomocysteinemic renal-transplant recipients. The effect of cholestyramine on intestinal absorption. In: Shils ME, Olson JA, Shike M, eds. Am.J.Clin.Nutr. Transplant Proc 2001;33:974-5. View abstract. A prescription form of vitamin B12 can be given as a shot. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. View abstract. Tee, E. S., Kandiah, M., Awin, N., Chong, S. M., Satgunasingam, N., Kamarudin, L., Milani, S., Dugdale, A. E., and Viteri, F. E. School-administered weekly iron-folate supplements improve hemoglobin and ferritin concentrations in Malaysian adolescent girls. Mechanism of vitamin B12 malabsorption in patients receiving colchicine. Neurology 2014;83(23):2158-66. De La Fourniere, F., Ferry, M., Cnockaert, X., Chahwakilian, A., Hugonot-Diener, L., Baumann, F., Nedelec, C., Buronfosse, D., Meignan, S., Fauchier, C., Attar, C., Belmin, J., and Piette, F. Vitamin B12 deficiency and dementia a multicenter epidemiologic and therapeutic study preliminary therapeutic trial [Deficience en vitamine B12 et etat dementiel etude epidemiologique multicentrique et therapeutique essai preliminaire]. View abstract. View abstract. View abstract. Vitamin B12 deficiency can be treated with vitamin B12. Arch.Intern.Med 1-8-2007;167(1):21-30. Thromb.Haemost. Int J Prev Med. 1988;48(3):595-600. Luchsinger JA, Tang MX, Miller J, et al. Effect of maternal vitamin B12 supplementation on cognitive outcomes in south Indian children: A randomized controlled clinical trial. Dalbeni A, Bevilacqua M, Teani I, Normelli I, Mazzaferri F, Chiarioni G. Excessive vitamin B12 and poor outcome in COVID-19 pneumonia. III. McNulty, H., Pentieva, K., Hoey, L., and Ward, M. Homocysteine, B-vitamins and CVD. Pernicious anemia. The aim of the present study was to evaluate the effect of dose and repeated administration on the pharmacokinetics of cyanocobalamin in rats. Sedjo, R. L., Inserra, P., Abrahamsen, M., Harris, R. B., Roe, D. J., Baldwin, S., and Giuliano, A. R. Human papillomavirus persistence and nutrients involved in the methylation pathway among a cohort of young women. Fleming, A. F., Martin, J. D., Hahnel, R., and Westlake, A. J. Tardif JC. Ho, G. Y., Palan, P. R., Basu, J., Romney, S. L., Kadish, A. S., Mikhail, M., Wassertheil-Smoller, S., Runowicz, C., and Burk, R. D. Viral characteristics of human papillomavirus infection and antioxidant levels as risk factors for cervical dysplasia. Baltimore, MD: Williams & Wilkins, 1999. Circulation 2002;106(Suppl II):741. View abstract. Sato, Y., Honda, Y., Iwamoto, J., Kanoko, T., and Satoh, K. Homocysteine as a predictive factor for hip fracture in stroke patients. View abstract. Yeo, A. S., Schiff, M. A., Montoya, G., Masuk, M., van Asselt-King, L., and Becker, T. M. Serum micronutrients and cervical dysplasia in Southwestern American Indian women. Waters DD, Alderman EL, Hsia J, et al. View abstract. JAMA 2009;302:2119-26. Homocysteine, B vitamins, and cognitive deficit in the elderly. Stolzenberg-Solomon RZ, Pietinen P, Barrett MJ, et al. Vitamin B12: Fact sheet for health professionals. View abstract. View abstract. Garcia A, Paris-Pombo A, Evans L, et al. View abstract. Nervenarzt 2012;83(4):521-532. How we vet brands and products. Correlation of folate, vitamin B12 and homocysteine plasma levels with depression in an elderly Greek population. Ophthalmic Epidemiol. Treasure Island, FL: StatPearls Publishing; 2020. Effect of combined folic acid, vitamin B(6), and vitamin B(12) on colorectal adenoma. View abstract. View abstract. Effect in pregnant subjects of varying amounts of added folic acid. View abstract. A person is diagnosed with vitamin B12 deficiency if the amount of vitamin B12 in their blood is less than 150 per mL. View abstract. Objectives To compare the effectiveness of oral versus intramuscular (IM) vitamin B12 (VB12) in patients aged ≥65 years with VB12 deficiency. Neurology 10-26-2010;75(17):1540-1547. Psychopharmacology (Berl) 1992;109(4):489-496. What are some effects of vitamin B12 on health? View abstract. Malabsorption of vitamin B12 during treatment with slow-release potassium chloride. Malvern, PA: Lea & Febiger, 1994. J Clin.Psychiatry 2008;69(8):1203-1209. View abstract. Vitamin B12 intramuscular injections (a shot that goes into the muscle). View abstract. Peterson, J. C. and Spence, J. D. Vitamins and progression of atherosclerosis in hyper-homocyst(e)inaemia. Am J Clin Nutr 1993;57(4):506-511. Vitamin B12. A., Stewart, D. H., Feldman, M. J., and Pozez, A. L. Smoke inhalation injury in a pregnant patient: a literature review of the evidence and current best practices in the setting of a classic case. View abstract. View abstract. View abstract. VII Malabsorption of B12 during treatment with potassium citrate. Epub 2019 May 22. Atherosclerosis 2005;181(1):131-135. Am J Clin Nutr 1999;69(1):80-86. Aging (Milano) 1993;5:63-71.. View abstract. View abstract. 1990;60(1):81-88. A., Wu, K., Helzlsouer, K. J., Strickland, P. T., Selhub, J., and Yager, J. D. COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk. Seine zentrale Bedeutung für die . Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Muhilal, Murdiana, A., Azis, I., Saidin, S., Jahari, A. Sood, S. K., Ramachandran, K., Mathur, M., Gupta, K., Ramalingaswamy, V., Swarnabai, C., Ponniah, J., Mathan, V. I., and Baker, S. J. W.H.O. Wu, K., Helzlsouer, K. J., Comstock, G. W., Hoffman, S. C., Nadeau, M. R., and Selhub, J. Most people can prevent vitamin B12 deficiency by consuming enough of it in their diet. View abstract. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. At least 6% of people who are 60 years or over. 2000;83(8):825-831. Calcif Tissue Int. Most studies show that low blood levels of vitamin B12 don’t affect the risk of cognitive decline in older people, regardless of whether they have dementia or Alzheimer’s disease. Med Toxicol Adverse Drug Exp 1988;3:430-48. Houston DK, Johnson MA, Nozza RJ, et al. JAMA 1998;279:359-64. Other symptoms of vitamin B12 deficiency include problems with balance, depression, confusion, dementia, poor memory, and soreness of the mouth or tongue. The risk of cervical cancer in relation to serum concentrations of folate, vitamin B12, and homocysteine. Panth, M., Shatrugna, V., Yasodhara, P., and Sivakumar, B. Metformin is used to treat prediabetes and diabetes. View abstract. Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events. Callaghan TS, Hadden DR, Tomkin GH. Zapletal C, Heyne S, Golling M, et al. Advertising on our site helps support our mission. View abstract. Researchers had previously believed that vitamin B-12, when combined with folic acid (vitamin B-9) and vitamin B-6, might prevent diseases of the heart and blood vessels by reducing the levels of an amino acid in the blood (homocysteine). View abstract. Is high vitamin B12 status a cause of lung cancer? Srinivasan K, Thomas T, Kapanee AR, et al. Cardiovasc Drugs Ther 1997;11:485-91. barley grass. Clin Nephrol 2013;79(4):323-5. View abstract. If neurological problems develop from vitamin B12 deficiency, they may not be reversible. Pain Manag 2014;4(3):191-6. Giuliano, A. R., Papenfuss, M., Nour, M., Canfield, L. M., Schneider, A., and Hatch, K. Antioxidant nutrients: associations with persistent human papillomavirus infection. 2012;24(3):225-238. View abstract. Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment. Am J Hematol 2002;69:239-46.. View abstract. Grundt, H., Nilsen, D. W., Hetland, O., Mansoor, M. A., Aarsland, T., and Woie, L. Atherothrombogenic risk modulation by n-3 fatty acids was not associated with changes in homocysteine in subjects with combined hyperlipidaemia. View abstract. 1975;45(4):411-418. Am.J Clin.Nutr 2005;82(6):1320-1326. View abstract. Vitamin B12 in dietary supplements isn’t attached to protein and doesn’t require the first step. Adults need around 2.4 micrograms (mcg) of vitamin B12 a day, and people who are pregnant or breastfeeding need more. Lancet 5-16-1998;351(9114):1477-1482. Lancet 1-24-1998;351(9098):263. Folate-related nutrients, genetic polymorphisms, and colorectal cancer risk: The Fukuoka Colorectal Cancer Study. Some research shows that people with high levels of vitamin B12 have a higher risk of cancer. Gut 2013;62(5):766-73. 2018;3(3):CD004655. Effect of histamine H2 receptor antagonists on vitamin B12 absorption. It can also be added to foods or supplements. 1992;5(2):125-129. Drug-induced malabsorption of vitamin B12. Association between B-group vitamins and venous thrombosis: systematic review and meta-analysis of epidemiological studies. Exp.Biol.Med.(Maywood.) Rezaei S, Shab-Bidar S, Abdurahman AA, Djafarian K. Oxcarbazepine administration and the serum levels of homocysteine, vitamin B12 and folate in epileptic patients: A systematic review and meta-analysis. Ubbink, J. Sleep 1991;14:414-8. View abstract. Liem A, Reynierse-Buitenwerf GH, Zwinderman AH, et al. Am J Clin Nutr. Overview Vitamin B12 is an essential vitamin found in foods such as meat, fish, and dairy. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Reade, M. C., Davies, S. R., Morley, P. T., Dennett, J., and Jacobs, I. C. Review article: management of cyanide poisoning. Int.J.Cancer 11-20-2005;117(4):629-637. Cochrane Database Syst Rev. View abstract. 1997;20(2):295-300. View abstract. Diabetes Res Clin Pract 1994;24(3):173-180. 2020;19(1):111. Livshits Z, Lugassy DM, Shawn LK, Hoffman RS. 2016;16(7):869-81. What kinds of vitamin B12 dietary supplements are available? Am.J.Perinatol. View abstract. Am.J Clin.Nutr 2005;81(5):1155-1162. Kendall, A. C., Jones, E. E., Wilson, C. I., Shinton, N. K., and Elwood, P. C. Folic acid in low birthweight infants. Any mention in this publication of a specific product or service, or recommendation from an organization or professional society, does not represent an endorsement by ODS of that product, service, or expert advice. View abstract. Indian Pediatr. Arch Intern Med 2002;162:2251-2. Kellerman RD, et al. Selective inhibition of vitamin B12 absorption by para-aminosalicylic acid. Get useful, helpful and relevant health + wellness information. Depending on the cause of your vitamin B12 deficiency, you may have to only take medication for a short amount of time, or you may have to take medication for the rest of your life. Langan RC, Goodbred AJ. Sharma TK, Vardey SK, Sitaraman S. Evaluate the Effect of Valproate Monotherapy on the Serum Homocysteine, Folate and Vitamin B12 Levels in Epileptic Children. Ann Pharmacother 2003;37:490-3. Was sollten Sie vor der Anwendung von Vitamin B12-ratiopharm ® N beachten? Foods contain vitamins, minerals, dietary fiber, and other components that benefit health. 1998;7(6):537-544. Pernicious anemia, a deficiency in the production of red blood cells due to a lack of vitamin B12, can cause permanent neurological damage that can lead to death if it is untreated. The Swiss Heart Study: A randomized controlled trial. 2016;18(81):93-7. Malabsorptive effects of neomycin in commonly used doses. Green, S., Buchbinder, R., Barnsley, L., Hall, S., White, M., Smidt, N., and Assendelft, W. Acupuncture for lateral elbow pain. Verhaeverbeke I, Mets T, Mulkens K, Vandewoude M. Normalization of low vitamin B12 serum levels in older people by oral treatment. van Wijngaarden JP, Swart KM, Enneman AW, et al. Mackey, A. D. and Picciano, M. F. Maternal folate status during extended lactation and the effect of supplemental folic acid. Vitamin B12 is a nutrient that helps keep your body's blood and nerve cells healthy and helps make DNA, the genetic material in all of your cells. Seshadri, S., Shah, A., and Bhade, S. Haematologic response of anaemic preschool children to ascorbic acid supplementation. View abstract. Ford, A. H., Flicker, L., Thomas, J., Norman, P., Jamrozik, K., and Almeida, O. P. Vitamins B12, B6, and folic acid for onset of depressive symptoms in older men: results from a 2-year placebo-controlled randomized trial. Herrmann H. Prevention of cardiovascular events after percutaneous coronary intervention. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Kathiravan M, Kavitha S, Shanthi R. To determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients. View abstract. J.Gastroenterol.Hepatol. Thomson, S. W., Heimburger, D. C., Cornwell, P. E., Turner, M. E., Sauberlich, H. E., Fox, L. M., and Butterworth, C. E. Effect of total plasma homocysteine on cervical dysplasia risk. Bostom A, Shemin D, Gohh R, et al. Canker sores. View abstract. Gastric acid inhibitors Blood Health Vitamin B12 is an important factor in helping the body produce healthy red blood cells. Int.J.Geriatr.Psychiatry 2012;27(6):592-600. 2020 Dec 16;8:e10406. Eur J Pediatr. View abstract. View abstract. Secondary prevention with folic acid: effects on clinical outcomes. View abstract. 2021;13(2):395. Arch Intern Med 2005;165:1167-72. Nagata, C., Shimizu, H., Yoshikawa, H., Noda, K., Nozawa, S., Yajima, A., Sekiya, S., Sugimori, H., Hirai, Y., Kanazawa, K., Sugase, M., and Kawana, T. Serum carotenoids and vitamins and risk of cervical dysplasia from a case-control study in Japan. It is usually in a form called cyanocobalamin. [1] Eine Vielzahl von Anzeichen und Symptomen können auftreten, insbesondere eine Blutarmut und neurologische Störungen. A. View abstract. People whose diet is . Prevention Outlook / Prognosis Living With Overview What is vitamin B12 deficiency? Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials. Penninx BW, Guralnik JM, Ferrucci L, et al. Homocysteine lowering effect of different multivitamin preparations in patients with end-stage renal disease. It is required by animals, which use it as a cofactor in DNA synthesis, and in both fatty acid and amino acid metabolism. Nutrients 2021;13(3):923. 2021;147(1):9-15. Cochrane.Database.Syst.Rev 2002;(1):CD003527. Dig Dis Sci 1982;27:723-7. J Am Board Fam Med 2009;22:9-16. Am J Hypertens. J Am Coll Nutr 1994;13:584-91. 1992;85(11):686-687. View abstract. Because of this, their body cannot properly absorb vitamin B12, which causes a vitamin B12 deficiency. Carpentier JL, Bury J, Luyckx A, et al. View abstract. 2010;9(9):855-865. Taking vitamin B12 by mouth, alone or with folic acid and vitamin B6, doesn't seem to improve mental function in elderly people. A. Normohomocysteinaemia and vitamin-treated hyperhomocysteinaemia are associated with similar risks of cardiovascular events in patients with premature peripheral arterial occlusive disease. This activity reviews the indications, action, and possible contraindications for cobalamin as a valuable agent. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4953733/. Effects of a high-dose concentrate of n-3 fatty acids or corn oil introduced early after an acute myocardial infarction on serum triacylglycerol and HDL cholesterol. The controversy over homocysteine and cardiovascular risk. BJOG. View abstract. Am.J Clin.Nutr 1973;26(6):591-594. Sun, Y., Lai, M. S., and Lu, C. J. At least 4% of people aged 40 to 59 years old. View abstract. Average daily recommended amounts for different ages are listed below in micrograms (mcg): Vitamin B12 is found naturally in a wide variety of animal foods, and manufacturers add it to some fortified foods. Sci Rep 2021;11(1):13361. "Egg yolks contain more vitamin B12 than egg whites," says Taylor. Information from this source is evidence-based and objective, and without commercial influence. Kang, J. H., Cook, N., Manson, J., Buring, J. E., Albert, C. M., and Grodstein, F. A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease. If you have already been diagnosed with vitamin B12 deficiency and are experiencing new or concerning symptoms, be sure to reach out to your healthcare provider. View abstract. The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. Ruscin JM, Page RL, Valuck RJ. Hodis, H. N., Mack, W. J., LaBree, L., Mahrer, P. R., Sevanian, A., Liu, C. R., Liu, C. H., Hwang, J., Selzer, R. H., and Azen, S. P. Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS). JAMA 8-20-2008;300(7):795-804. Malouf, R. and Grimley, Evans J. Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. View abstract. B., Ueland, P. M., Nesthus, I., Nygard, O., Schneede, J., Vollset, S. E., and Refsum, H. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). Jacques, P. F., Selhub, J., Bostom, A. G., Wilson, P. W., and Rosenberg, I. H. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. B., MacFarlane, P. W., and Westendorp, R. G. Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease. Roberts, P. M., Arrowsmith, D. E., Lloyd, A. V., and Monk-Jones, M. E. Effect of folic acid treatment on premature infants. View abstract. View abstract. J.Lab Clin.Med. Nutr Cancer 2009;61(4):447-456. McGraw Hill; 2021. https://accessmedicine.mhmedical.com. Vitamin B(12) cream containing avocado oil in the therapy of plaque psoriasis. View abstract. Lancet 1990;336:392-5.. View abstract. Some provide doses of vitamin B12 that are much higher than recommended amounts, such as 500 mcg or 1,000 mcg, but your body absorbs only a small percentage of it. Cochrane Database Syst Rev. No effect of vitamin B-12 treatment on cognitive function and depression: a randomized placebo controlled study. View abstract. View abstract. Arch.Dis.Child 1972;47(254):631-634. Lindenbaum J, Healton EB, Savage DG, et al. While breastfeeding, the RDA is 2.8 mcg daily. Higher vitamin B12 level at Parkinson's disease diagnosis is associated with lower risk of future dementia. 6. Kanai T, Takagi T, Masuhiro K, et al. View abstract. B12 also works with other B vitamins to improve certain functions. J.Nutr.Biochem. Having a hard time remembering things or getting confused easily. Blanchette, V., Bell, E., Nahmias, C., Garnett, S., Milner, R., and Zipursky, A. PLoS One. Shanghai Journal of acupuncture and moxibustion 1997;16(6):20. View abstract. 1997;90(8):519-524. Cyanocobalamin - a case for withdrawal: discussion paper. Experiencing a change in the way you feel and behave. Lancet 3-30-2002;359(9312):1108-1113. Woodside, J. V., Young, I. S., Yarnell, J. W., McMaster, D., and Evans, A. E. The effects of oral vitamin supplementation on cardiovascular risk factors. Vitamin B12 is an important vitamin that your body needs to be healthy. Br J Rheumatol. First, hydrochloric acid in your stomach removes vitamin B12 from the food it was in. van Oijen MG, Laheij RJ, Peters WH, et al. Circulation 2003;107:947-53.. View abstract. Vitamin B12 is also available in a form that’s dissolved under your tongue (called sublingual vitamin B12). https://www.uptodate.com/contents/search. Am J Clin Nutr. View abstract. van den Berg, M., Franken, D. G., Boers, G. H., Blom, H. J., Jakobs, C., Stehouwer, C. D., and Rauwerda, J. View abstract. 1986;80(2):211-233. Psychiatry Clin Neurosci 1998;52:483-90. Design Pragmatic, randomised, non-inferiority, multicentre trial in 22 primary healthcare centres in Madrid (Spain). View abstract. Is low-dose oral cobalamin enough to normalize cobalamin function in older people? Hankey GJ, Eikelboom JW, Yi Q, et al. This activity will highlight the mechanism of action, adverse event profile, and other key factors . Arch Neurol 2007;64:86-92. View abstract. Most people get enough vitamins from the foods they eat. JAMA 1961;175:187-90. Urban legends: recurrent aphthous stomatitis. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Gougeon L, Payette H, Morais JA, Gaudreau P, Shatenstein B, Gray-Donald K. Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: the Quebec Longitudinal Study on Nutrition and Aging. View abstract. BMC Geriatr 2013;13:88. Arterioscler.Thromb.Vasc.Biol. View abstract. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Singh C, Kawatra R, Gupta J, Awasthi V, Dungana H. Therapeutic role of vitamin B12 in patients of chronic tinnitus: A pilot study. Am.J Transplant. View abstract. Passeri M, Cucinotta D, Abate G, et al. 2002;11(4):353-359. Haematological adverse effects of histamine H2-receptor antagonists. Saltzman, E., Mason, J. Cancer Epidemiol.Biomarkers Prev. Kwok T, Tang C, Woo J, et al. Am.J Clin.Nutr 1989;50(2):332-338. Chen, S. H., Hung, C. S., Yang, C. P., Lo, F. S., and Hsu, H. H. Coexistence of megaloblastic anemia and iron deficiency anemia in a young woman with chronic lymphocytic thyroiditis. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. 26th ed. https://www.dietaryguidelines.gov. Am J Clin Nutr. Tamai, H., Kim, H. S., Arai, H., Inoue, K., and Mino, M. Developmental changes in alpha-tocopherol, especially during infantile period. But other research shows that the risk of cancer is higher in people with low levels of vitamin B12 or that vitamin B12 levels don’t affect cancer risk. Herbert V, Jacob E, Wong KT, et al. Nenseter, M. S., Osterud, B., Larsen, T., Strom, E., Bergei, C., Hewitt, S., Holven, K. B., Hagve, T. A., Mjos, S. A., Solvang, M., Pettersen, J., Opstvedt, J., and Ose, L. Effect of Norwegian fish powder on risk factors for coronary heart disease among hypercholesterolemic individuals. N.Engl.J Med 5-13-1999;340(19):1449-1454. Buzina, R., Jusic, M., Milanovic, N., Sapunar, J., and Brubacher, G. The effects of riboflavin administration on iron metabolism parameters in a school-going population. NORVIT: Homocysteine lowering and cardiovascular events after acute myocardial infarction. Am J Kidney Dis 2013;62(2):395. N Engl J Med 2001;345:1593-600. View abstract. View abstract. information submitted for this request. View abstract. Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study. Burland, W. L., Simpson, K., and Lord, J. 2017;45:87-94. Vitamin B12, or cobalamin, is naturally found in animal foods. Am J Med 1998;104:422-30. View abstract. Updated: 5. If you have risk factors for developing vitamin B12 deficiency or are experiencing symptoms, be sure to contact your doctor to get a blood test to check your levels. DeMaio, S. J., King, S. B., III, Lembo, N. J., Roubin, G. S., Hearn, J. Effect of Vitamin B12 Injection on the Vocal Performance of Professional Singers: A Randomized, Double-blind, Placebo-Controlled, Crossover Trial. Carcinogenesis 2001;22(10):1661-1665. As a result, they have trouble absorbing vitamin B12 from foods and dietary supplements. If a significant amount of your B12 is inactive, a test may show that you have normal vitamin B12 levels. Pernicious anemia. Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. View abstract.