Szulc M, Świątkowska-Stodulska R, Pawłowska E, Derwich M. Int J Mol Sci. 2023 Apr 27;13(5):603. doi: 10.3390/metabo13050603. Hi Robin, Dr. Hans Selye showed that when adequate progesterone was available, the need for adrenal hormones declines significantly. Effect of calcitriol treatment on Hashimoto's thyroiditis with hypothyroidism. Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Vitamin D: modulator of the immune system. The Effect of Vitamin D Adequacy on Thyroid Hormones and Inflammatory Markers after Bariatric Surgery. 33 Also, HDL cholesterol concentrations improved in the euthyroid Hashimoto group after treatment. Changes in TSH levels are always relative to where they started but you can generally think about anything that lowers TSH naturally to be a good thing for Hashimoto’s patients (it means the thyroid is working better on its own). This is an important distinction, and supplementing with vitamin D is definitely NOT hormone replacement therapy. Yet, increasing evidence is showing that Vitamin D, and other fat-soluble vitamin deficiencies, are playing a central role in both Hashimoto’s and hypothyroidism. Gouni-Berthold I, Krone W, Berthold HK. Ke W, Sun T, Zhang Y, He L, Wu Q, Liu J, Zha B. Endocr J. More randomized, double-blind, placebo-controlled trials with longer follow-up durations are required to confirm these preliminary findings. Hi! Eyles DW, Smith S, Kinobe R, Hewison M, McGrath. A manual review of the reference lists from primary or review articles was undertaken to identify any additional relevant studies. BTW, I love the ADK oil. & Y.C.) Vitamin D toxicity rare in people who take supplements, researchers report. Epidemiological surveys show that vitamin D deficiency rates are as high as 50%-90% in HT patients. Unauthorized use of these marks is strictly prohibited. HHS Vulnerability Disclosure, Help Mazokopakis EE, Papadomanolaki MG, Tsekouras KC, Evangelopoulos AD, Kotsiris DA, Tzortzinis AA. In addition, studies show that vitamin D3 is more potent at raising 25-hydroxy vitamin D levels compared to the D2 version. Getting vitamin D from the sun is not as easy as it sounds, though, because there are many factors that can reduce how effective sun exposure can be for vitamin D synthesis. The bias assessment of all eight trials is detailed in Figure 2. Need better symptom control? Patients with Hashimoto's thyroiditis had significantly lower vitamin D concentrations compared with the controls (9.37±0.69 ng/mL vs 11.95±1.01 ng/mL, p < 0.05, respectively). 2016 Feb;86 (1-2):9-17. doi: 10.1024/0300-9831/a000269. The search strategies for the other databases are presented in the appendix file (see supplementary materials). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). A subgroup analysis demonstrated that vitamin D supplementation for >3 months resulted in a decrease in TPOAb titre (SMD: –1.66, 95% CI: –2.91, –0.41) but treatment ≤3 months was ineffective. Int J Mol Sci. Thank in advance. Iwamoto J, Yeh JK, Takeda T, Ichimura S, Sato Y. Beyond bone health, vitamin D as 25 (OH)D is used by nearly every cell in the . For example, a recent meta-analysis involving 26 observational studies found that the 25-hydroxyvitamin D (25(OH)D) level was significantly lower in patients with HT than in healthy controls. If you are taking a vitamin D supplement then check to make sure you are using the D3 formulation and not the D2 formulation. Kim D. The Role of Vitamin D in Thyroid Diseases. This current meta-analysis had several limitations as follows: (i) the power of the analysis may be restricted because of the limited study numbers and population sizes; (ii) there was significant heterogeneity among the included studies; (iii) most of the included studies were conducted in China, which affects the extrapolation of the conclusions to other populations to some extent; (iv) only published data were included, which may lead to a reporting bias by overestimating the effect of vitamin D. The findings of this current meta-analysis suggest that vitamin D supplementation reduces TGAb and TPOAb titre in patients with HT. All eight studies reported data on TPOAb, but there was significant heterogeneity (χ2 = 150.02; I You state that, “… Vitamin D levels should ideally be between 50 to 60 nmol/l (20 to 24 ng/ml).” This is much lower than most sites, which typically recommend a minimum level of 75 or 80 nmol/l, and preferably 100 or higher. The .gov means it’s official. But with deficiency rates as high as 76%, the odds are definitely on your side. National Library of Medicine Hashimoto's thyroiditis (HT), also called chronic lymphocytic thyroiditis, is the most prevalent organ‐specific autoimmune disorder as well as the most common cause of thyroid hypofunction, with an incidence of 0.3-1.5 cases per 1000 people in developed countries. A meta-analysis of six randomized controlled trials published in 2018 showed that vitamin D supplementation could decrease serum antibody titres in patients with HT in the short-term (approximately 6 months). What do sunlight, winter, and how you are feeling have in common? 2023 Jan;71(1):1. A systematic search of publications listed in electronic databases (PubMed®, MEDLINE®, EMBASE, The Cochrane Library, China National Knowledge Infrastructure [CNKI]) from inception to August 2020 was undertaken using a set of key words. All evaluations were repeated after 2 months of treatment. 2023 May;80(2):346-354. doi: 10.1007/s12020-022-03270-x. Lower concentrations of TNF-α was a predictor of lower levels of vitamin D. Differences in the association between HT and vitamin D insufficiency remain unresolved in the literature. A subgroup analysis was performed based on the form of vitamin D administration. Any ideas? This meta-analysis included randomized controlled clinical trials identified by a systematic search of electronic databases (PubMed®, MEDLINE®, EMBASE, The Cochrane Library, China National Knowledge Infrastructure) from inception to August 2020. Galușca D, Popoviciu MS, Babeș EE, Vidican M, Zaha AA, Babeș VV, Jurca AD, Zaha DC, Bodog F. Medicina (Kaunas). Six studies provided data on TGAb, but there was significant heterogeneity (χ2 = 75.12; I Epub 2022 Dec 13. 2017 Apr;125(4):229-233. doi: 10.1055/s-0042-123038. I am taking synthroid 25mcg but an euthyroid with or without it. I don’t have a lot of the usual symptoms like fatigue, brain fog, etc. The positive correlation between free T4 and vitamin D concentrations suggests that adequate levothyroxine replacement in HT would be an essential factor in maintaining vitamin D at sufficient levels. My father was hypo and my eldest brother was hyper. 20 On the Centennial of Vitamin D-Vitamin D, Inflammation, and Autoimmune Thyroiditis: A Web of Links and Implications. 19 Hashimoto's thyroiditis (HT), also known as autoimmune thyroiditis and first described in 1912 by Hakaru Hashimoto, is the leading cause of primary hypothyroidism. I show you exactly how to make the safest and most effective calcium carbonate supplement from eggshells here: Eggshell Calcium Supplement. Hashimoto's thyroiditis is an autoimmune condition that gradually destroys thyroid tissue via lymphocytes, which are white blood cells that are part of your immune system ( 1 ). Unfortunately, the link between vitamin D and free thyroid hormone levels is not as straightforward as you might think. Baker T. Vitamin D insufficiency, low rate of DNA methylation in black teens may increase disease risk. This meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Authors government site. Be careful with paleo-type diets as they are quite thyroid suppressive. Because so many patients with Hashimoto’s thyroiditis suffer from vitamin D deficiency and because of its impact on both the thyroid and immune system, using vitamin D supplements may be an easy way to reverse a deficiency. That's huge! Well, the calcium carbonate supplement is easy. The good news is that optimizing your vitamin D level is still a good idea even if you’ve already been diagnosed with Hashimoto’s. Immune disorders in Hashimoto's thyroiditis: what do we know so far? Well, you’re not fairing any better seeing as 94 percent to 98 percent of hypothyroidism sufferers are deficient too. Bhakat B, Pal J, Das S, Charaborty SK, SircarMedical NR, Kolkata, RGKar, NorthBengal, Siliguri. Hopefully, these benefits were enough to get you excited about using vitamin D which brings us to our next question: How much vitamin D should you take if you have Hashimoto’s and want to supplement? If there was significant heterogeneity, a subgroup analysis was conducted using two factors (treatment duration, form of vitamin D administration) to find the source of the heterogeneity. What we don’t know is which comes first or which one causes the other. Jingwen Zhang and Yuting Chen independently carried out the literature search and screening of articles. Assessment of the reporting quality of randomised controlled trials for vitamin D supplementation in autoimmune thyroid disorders based on the CONSORT statement. Terms & Conditions. Too much of one can create a deficiency in the other. I am so thankful that I found you! Clipboard, Search History, and several other advanced features are temporarily unavailable. Bookshelf The TPOAb results showed Z = 1.61.pr > |Z| = 0.108, suggesting no obvious publication bias in the references included in this meta-analysis (Figure 7). P < 0.10 indicated the presence of publication bias. J Assoc Physicians India. This content is strictly the opinion of Dr. Westin Childs and is for educational and information purposes only. Nutrition as Prevention of Diet-Related Diseases-A Cross-Sectional Study among Children and Young Adults with Down Syndrome. In general, the antibody titre is positively correlated with the extent of hypothyroidism. And DON’T use sunscreen for at least the first 30 mins to 60 in the sun…I never do. Hongyan Li helped edit the manuscript; Hong Li revised the manuscript. cardiovascular risk; hashimoto's thyroiditis; vitamin D. MeSH These aspects are all crucial to maintaining a healthy thyroid gland that is free from inflammation, disruption of thyroid hormones, and disruption of pituitary hormones. That is why UV produced D is the only way to get D, through your body’s internal wisdom. Thanks! Sensitivity analyses of the included studies: (a) sensitivity analysis for the studies about the effect of vitamin D supplementation on thyroid peroxidase antibody titre; (b) sensitivity analysis for the studies about the effect of vitamin D supplementation on thyroglobulin antibody titre.7–14. Arzt berichtet: Vitamin D kann von Hashimoto befreien Dr. Berndt Rieger - ganzheitlicher Endokrinologe und Schilddrüsenspezialist - schreibt auf seiner Webseite (2), dass jeder Mensch mit einer aktiven Hashimoto-Thyreoiditis einen niedrigen Vitamin-D-Spiegel habe. The results showed that vitamin D supplementation could decrease TPOAb titre in the subgroups that were treated with vitamin D3 (SMD: –1.48; 95% CI: –2.53, –0.42; P = 0.006), but not in the subgroups that were treated with vitamin D (SMD: –0.01; 95% CI: –0.35, 0.32; P = 0.945) (Figure 4B). There was significant heterogeneity between the studies. Mean platelet volume in euthyroid patients with Hashimoto's thyroiditis. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. official website and that any information you provide is encrypted “Vitamin D supplementation reduces thyroid peroxidase antibody levels in patients with autoimmune thyroid disease: An open-labeled randomized controlled trial” Indian Journal of Endocrinology and Metabolism, May-Jun 2016, https://pubmed.ncbi.nlm.nih.gov/27186560/, 2. Howland RH. Declaration of conflicting interest: The authors declare that there are no conflicts of interest. Published April 25, 2016. Hashimoto’s thyroiditis and Vitamin D deficiency go hand-in-hand. Altieri B, Muscogiuri G, Barrea L, Mathieu C, Vallone CV, Mascitelli L, et al. MayoClinic. A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients. Better nights sleep, no breast pain and more energy. One problem I have started having is that it seems like no matter what vitamin d3 I have taken, I have a problem with an urgent signal to urinate with usually low output. A proof of concept. Xu J, Zhu XY, Sun H, et al. TSH stands for thyroid-stimulating hormone and it’s the hormone that doctors frequently use to check how well your thyroid is working. Federal government websites often end in .gov or .mil. Vitamin A helps promote the production of T Regulatory Cells, which work to shut down the immune reaction. I cover this in detail here: https://www.forefronthealth.com/vitamin-a-and-hypothyroidism/. Epub 2017 Jan 10. Not only does vitamin D play an important role in your overall health but it also helps to regulate and control several aspects of thyroid function. This current meta-analysis evaluated additional recent randomized controlled trials and reached a similar conclusion. There are two main forms that vitamin D supplements come in and one is definitely better than the other. That’s why this article exists, to discuss whether or not you should use vitamin D if you have Hashimoto’s, how much you should take, the best way to get it, and much more. When you take oral D, you are telling your body that it is getting it, like it or not. Author contributions: Jingwen Zhang and Hong Li designed the study. © Restart Medical LLC. 2017 May;27(5):597-610. doi: 10.1089/thy.2016.0635. and transmitted securely. In other words, it’s less about prevention and more about management now. 2023 Jan;71(1):1. Epub 2017 Apr 11. 1 , 2 This autoimmune event is believed to be initiated by the activation of thyroid antigen‐specific . | Terms & Conditions | Privacy Policy | These statements have not been evaluated by the Food and Drug Administration.